Dept of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Wangfujing, Beijing, People's Republic of China.
Am J Clin Pathol. 2011 Nov;136(5):783-92. doi: 10.1309/AJCP7LO3NAYQKASZ.
The histopathologic features of 10 myxoid adrenocortical neoplasms were analyzed, and epidermal growth factor receptor (EGFR) expression, EGFR gene copy number, and EGFR gene mutations in the 10 tumors were detected by using immunohistochemical analysis, fluorescence in situ hybridization, and the Scorpion Amplification Refractory Mutation System (DxS, Manchester, England), respectively. Histologically, all 10 tumors varied in their myxoid composition, ranging from 20% to 95%. EGFR protein overexpression was more frequent in myxoid adrenocortical carcinomas (3/4) than in myxoid adrenocortical adenomas (0/6). However, EGFR mutations and EGFR amplification were rare. All patients with adenomas survived for the follow-up period with no recurrence of their tumors or evidence of metastatic disease; 3 patients with carcinoma died of the disease, and 1 is alive with disease. Myxoid changes in adrenocortical neoplasms can be present in adenomas and carcinomas. Detection of EGFR protein expression may be useful in the differential diagnosis between adrenocortical adenomas and adrenocortical carcinomas.
分析了 10 例黏液性肾上腺皮质肿瘤的组织病理学特征，应用免疫组化分析、荧光原位杂交和 Scorpion Amplification Refractory Mutation System（DxS，英国曼彻斯特）分别检测了这 10 个肿瘤中的表皮生长因子受体（EGFR）表达、EGFR 基因拷贝数和 EGFR 基因突变。组织学上，这 10 个肿瘤的黏液性成分各不相同，从 20%到 95%不等。黏液性肾上腺皮质癌（3/4）中 EGFR 蛋白过表达比黏液性肾上腺皮质腺瘤（0/6）更常见。然而，EGFR 突变和 EGFR 扩增很少见。所有腺瘤患者在随访期间均存活，肿瘤无复发或无转移疾病证据；3 例癌患者死于该疾病，1 例仍有疾病。黏液性改变在肾上腺皮质肿瘤中可以出现在腺瘤和癌中。检测 EGFR 蛋白表达可能有助于肾上腺皮质腺瘤和肾上腺皮质癌的鉴别诊断。
