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治疗人类不孕症和遗传疾病的新型生殖技术。

New reproductive technologies in the treatment of human infertility and genetic disease.

作者信息

Silver L M

机构信息

Department of Biology, Princeton University, NJ 08544-1014.

出版信息

Theor Med. 1990 Jun;11(2):103-10. doi: 10.1007/BF00489454.

DOI:10.1007/BF00489454
PMID:2203176
Abstract

In this paper I will discuss three areas in which advances in human reproductive technology could occur, their uses and abuses, and their effects on society. First is the potential to drastically increase the success rate and availability of in vitro fertilization and embryo freezing. Second is the ability to perform biopsies on embryos prior to the onset of pregnancy. Finally, I will consider the adding or altering of genes in embryos, commonly referred to as "genetic engineering". As new reproductive technologies pass from experimental models into the potential for medical utilization, I believe that it will be important for lawmakers everywhere to avoid the impulse to outlaw procedures that a society believes to be 'unnatural' at a first glance. Rather, I would hope that they can respond thoughtfully with legislation that serves two purposes--to protect the rights of couples to overcome infertility or to reduce the risk of genetic disease in their children-to-be, and more importantly, to protect children-to-be from the abuses that could result from some of the practices that I will discuss.

摘要

在本文中,我将探讨人类生殖技术可能取得进展的三个领域、它们的用途与滥用情况以及它们对社会的影响。首先是大幅提高体外受精和胚胎冷冻成功率及可及性的潜力。其次是在怀孕开始前对胚胎进行活检的能力。最后,我将探讨在胚胎中添加或改变基因,即通常所说的“基因工程”。随着新的生殖技术从实验模型走向医疗应用的可能性,我认为各地的立法者应避免冲动地将那些乍一看被社会认为“不自然”的程序定为非法。相反,我希望他们能够通过立法进行深思熟虑的回应,立法要达到两个目的——保护夫妇克服不孕不育或降低未来子女患遗传病风险的权利,更重要的是,保护未来子女免受我将讨论的某些做法可能导致的滥用。

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本文引用的文献

1
Abdominal pregnancy: review of current management and addition of 10 cases.腹腔妊娠:当前管理方法综述及10例病例补充
Obstet Gynecol. 1982 Aug;60(2):200-4.
2
A unique case of abdominal pregnancy: what are the minimal requirements for placental contact with the maternal vascular bed?一例罕见的腹腔妊娠病例:胎盘与母体血管床接触的最低要求是什么?
Am J Obstet Gynecol. 1986 Aug;155(2):394-6. doi: 10.1016/0002-9378(86)90839-2.
3
Germ-line transformation of mice.小鼠的种系转化
Annu Rev Genet. 1986;20:465-99. doi: 10.1146/annurev.ge.20.120186.002341.
4
Amplification and analysis of DNA sequences in single human sperm and diploid cells.单个人类精子和二倍体细胞中DNA序列的扩增与分析。
Nature. 1988 Sep 29;335(6189):414-7. doi: 10.1038/335414a0.
5
Medical ethics in Sweden.瑞典的医学伦理。
Theor Med. 1988 Oct;9(3):309-35. doi: 10.1007/BF00489705.
6
Advanced abdominal pregnancy in Muhimbili Medical Centre, Tanzania.坦桑尼亚穆希姆比利医疗中心的晚期腹腔妊娠。
Int J Gynaecol Obstet. 1986 Jun;24(3):169-76. doi: 10.1016/0020-7292(86)90094-9.