Division of Pediatric Oncology/Hematology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Leuk Res. 2012 Jan;36(1):6-13. doi: 10.1016/j.leukres.2011.09.028. Epub 2011 Oct 26.
The early history of leukemia reaches back 200 years. In 1811, Peter Cullen defined a case of splenitis acutus with unexplainable milky blood. Alfred Velpeau defined the leukemia associated symptoms, and observed pus in the blood vessels (1825). Alfred Donné detected a maturation arrest of the white blood cells (1844). John Bennett named the disease leucocythemia, based on the microscopic accumulation of purulent leucocytes (1845). That same year, Rudolf Virchow defined a reversed white and red blood cell balance. He introduced the disease as leukämie in 1847. Henry Fuller performed the first microscopic diagnose of a leukemic patient during life (1846). This gradual process brought us towards our current understanding of this complex disease.
白血病的早期历史可以追溯到 200 年前。1811 年，Peter Cullen 定义了一例伴有无法解释的乳白色血液的急性脾炎。Alfred Velpeau 定义了与白血病相关的症状，并观察到血管中有脓液（1825 年）。Alfred Donné 发现白细胞成熟停滞（1844 年）。John Bennett 根据显微镜下化脓性白细胞的堆积，将该疾病命名为leucocythemia（1845 年）。同年，Rudolf Virchow 定义了红白血细胞平衡的逆转。他在 1847 年将该疾病引入为leukämie。Henry Fuller 在患者生前首次进行了白血病的显微镜诊断（1846 年）。这个逐渐的过程使我们对这种复杂疾病的认识不断深入。
