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高容量中心行胰十二指肠切除术患者的手术 Apgar 评分可预测围手术期并发症。

Surgical Apgar score predicts perioperative morbidity in patients undergoing pancreaticoduodenectomy at a high-volume center.

机构信息

Department of Surgery and Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, 1100 Walnut Street, MOB, Suite 500, Philadelphia, PA 19107, USA.

出版信息

J Gastrointest Surg. 2012 Feb;16(2):275-81. doi: 10.1007/s11605-011-1733-1. Epub 2011 Oct 27.

DOI:10.1007/s11605-011-1733-1
PMID:22033701
Abstract

OBJECTIVES

Pancreaticoduodenectomy (PD) remains a procedure that carries considerable morbidity. Numerous studies have evaluated factors to predict patients at risk. The aim of this study was to determine whether the surgical Apgar score (SAS) predicts perioperative morbidity and mortality.

METHODS

We examined 553 patients undergoing successful PD between January 2000 and December 2010. Postoperative complications were graded using the Clavien scale, and the SAS (range, 0-10) was determined. The Cochran-Armitage test for trend was used to determine the association between grouped SAS scores (0-2, 3-4, 5-6, 7-8, and 9-10) and each of the outcomes.

RESULTS

The average patient age was 64 years, and there was an even distribution of males and females. There were 11 perioperative deaths (2%), 186 grade 2 or higher complications (34%), and 86 major complications (grades 3-5, 16%). Additionally, 61 patients developed pancreatic fistulae (11%). Statistical analysis determined that SAS was a significant predictor of grade 2 or higher complications (p < 0.0001), major morbidity (p = 0.01), and pancreatic fistula (p = 0.04) but not mortality (p = 0.20).

CONCLUSIONS

We demonstrate that the SAS is a significant predictor of perioperative morbidity for patients undergoing PD. This score should be used to identify patients at higher risk in order to prioritize use of postoperative critical care beds and hospital resources.

摘要

目的

胰十二指肠切除术(PD)仍然是一种具有相当高发病率的手术。许多研究已经评估了预测高危患者的因素。本研究旨在确定手术 Apgar 评分(SAS)是否可预测围手术期发病率和死亡率。

方法

我们检查了 2000 年 1 月至 2010 年 12 月期间成功接受 PD 的 553 例患者。术后并发症采用 Clavien 分级进行分级,SAS(范围为 0-10)。Cochran-Armitage 趋势检验用于确定分组 SAS 评分(0-2、3-4、5-6、7-8 和 9-10)与每个结果之间的关联。

结果

患者平均年龄为 64 岁,男女分布均匀。有 11 例围手术期死亡(2%),186 例 2 级或更高并发症(34%)和 86 例主要并发症(3-5 级,16%)。此外,61 例患者发生胰瘘(11%)。统计分析确定 SAS 是 2 级或更高并发症(p<0.0001)、主要发病率(p=0.01)和胰瘘(p=0.04)的显著预测因子,但不是死亡率(p=0.20)。

结论

我们证明 SAS 是 PD 患者围手术期发病率的重要预测因子。应使用该评分来识别风险较高的患者,以便优先使用术后重症监护病床和医院资源。

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