Long-term course and outcome of depression in later life.

Depression in later life is usually a recurrent illness and often a chronic one, associated with increased health care utilization, amplification of the disability born of concurrent medical illness, decreased quality of life, increased risk for suicide, and cognitive impairment. The good news, however, is that maintenance treatments work and have a demonstrably positive impact on long-term illness course. Treatment response is especially variable, or brittle, in patients aged over 70; yet maintenance treatment with combined medication and psychotherapy is able to significantly reduce long-term treatment response variability, ensuring continued wellness. Further evaluation of cost-effectiveness is necessary in order to improve reimbursement for effective long-term treatment.