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睡眠剥夺与抗抑郁治疗。

Sleep deprivation and antidepressant treatment.

作者信息

Voderholzer Ulrich

机构信息

Department of Psychiatry and Psychotherapy, Klinikum of the Albert-Ludwig-University, Hauptstrasse 5, 79104 Freiburg, Germany.

出版信息

Dialogues Clin Neurosci. 2003 Dec;5(4):366-9. doi: 10.31887/DCNS.2003.5.4/uvoderholzer.

DOI:10.31887/DCNS.2003.5.4/uvoderholzer
PMID:22033748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3181780/
Abstract

The mood-improving effect of sleep deprivation (SD) in depression is even today still not fully understood. Despite the fact that mood and cognitive functions are lowered by prolonged sleep loss and despite convincing data that insomnia is a strong risk factor for subsequent depression,(1) acute SD for one night or even partial SD in the second half of the night improves mood in about 60% of depressed patients the day after.(2,3) In this respect, among alt types of antidepressant treatments, SD elicits the fastest results, faster even than electroconvulsive therapy. Many authors correlate the likelihood of responding to SD with clinical variables. A summary of predictors is listed in Table I.

摘要

睡眠剥夺（SD）对抑郁症患者情绪改善的作用，即使在今天仍未被完全理解。尽管长期睡眠不足会导致情绪和认知功能下降，且有确凿数据表明失眠是后续发生抑郁症的强烈危险因素，（1）但一夜的急性睡眠剥夺甚至仅是后半夜的部分睡眠剥夺，都能使约60%的抑郁症患者在次日情绪得到改善。（2,3）在这方面，在所有类型的抗抑郁治疗中，睡眠剥夺产生的效果最快，甚至比电休克治疗还要快。许多作者将对睡眠剥夺产生反应的可能性与临床变量相关联。预测因素总结见表I。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/450b/3181780/f17aa15225af/DialoguesClinNeurosci-5-366-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/450b/3181780/e6036ce163b6/DialoguesClinNeurosci-5-366-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/450b/3181780/d29822063288/DialoguesClinNeurosci-5-366-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/450b/3181780/f17aa15225af/DialoguesClinNeurosci-5-366-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/450b/3181780/e6036ce163b6/DialoguesClinNeurosci-5-366-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/450b/3181780/d29822063288/DialoguesClinNeurosci-5-366-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/450b/3181780/f17aa15225af/DialoguesClinNeurosci-5-366-g003.jpg

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本文引用的文献

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Primary insomnia: a risk factor to develop depression?原发性失眠：是发展为抑郁症的一个风险因素？
J Affect Disord. 2003 Sep;76(1-3):255-9. doi: 10.1016/s0165-0327(02)00072-1.
2
Is the antidepressive effect of sleep deprivation stabilized by a three day phase advance of the sleep period? A pilot study.睡眠时间提前三天是否能稳定睡眠剥夺的抗抑郁作用？一项初步研究。
Eur Arch Psychiatry Clin Neurosci. 2003 Apr;253(2):68-72. doi: 10.1007/s00406-003-0408-7.
3
Sleep phase advance and lithium to sustain the antidepressant effect of total sleep deprivation in bipolar depression: new findings supporting the internal coincidence model?
睡眠相位提前与锂盐维持双相抑郁中完全睡眠剥夺的抗抑郁作用：支持内源性巧合模型的新发现？
J Psychiatr Res. 2001 Nov-Dec;35(6):323-9. doi: 10.1016/s0022-3956(01)00034-6.
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Serum thyrotropin concentrations and bioactivity during sleep deprivation in depression.抑郁症患者睡眠剥夺期间的血清促甲状腺激素浓度及生物活性
Arch Gen Psychiatry. 2001 Jan;58(1):77-83. doi: 10.1001/archpsyc.58.1.77.
5
Acute antidepressant effects of intravenous hydrocortisone and CRH in depressed patients: a double-blind, placebo-controlled study.静脉注射氢化可的松和促肾上腺皮质激素释放激素对抑郁症患者的急性抗抑郁作用：一项双盲、安慰剂对照研究。
Am J Psychiatry. 2000 Aug;157(8):1334-7. doi: 10.1176/appi.ajp.157.8.1334.
6
Total sleep deprivation combined with lithium and light therapy in the treatment of bipolar depression: replication of main effects and interaction.完全睡眠剥夺联合锂盐及光照疗法治疗双相抑郁：主要效应及相互作用的重复验证
Psychiatry Res. 2000 Jul 24;95(1):43-53. doi: 10.1016/s0165-1781(00)00164-5.
7
How to preserve the antidepressive effect of sleep deprivation: A comparison of sleep phase advance and sleep phase delay.如何保持睡眠剥夺的抗抑郁作用：睡眠相位提前与睡眠相位延迟的比较。
Eur Arch Psychiatry Clin Neurosci. 1999;249(5):231-7. doi: 10.1007/s004060050092.
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Lancet. 1999 Oct 23;354(9188):1435-9. doi: 10.1016/S0140-6736(99)01376-8.
9
Rate of switch from depression into mania after therapeutic sleep deprivation in bipolar depression.双相抑郁患者经治疗性睡眠剥夺后从抑郁转为躁狂的发生率。
Psychiatry Res. 1999 Jun 30;86(3):267-70. doi: 10.1016/s0165-1781(99)00036-0.
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