Schilgen B, Bischofs W, Blaszkiewicz F, Bremer W, Rudolf G A, Tölle R
Arzneimittelforschung. 1976;26(6):1171-3.
Sleep deprivation (SD) has been proved to be an effective measure of antidepressive treatment (especially in endogenous depression). In a new study, 125 SD were examined on 93 depressed patients. The therapeutic benefit of SD on endogenous depression consists not only of the nightly clear up but also of provoking or improving a typical day wave the day after DS. A period of at least 36 h is necessary to survey the total effect of this method. The best results are achieved in patients with severe endogenous depression, especially in those with the typical day wave and distinct somatic symptoms. The effect of partial SD (for the second half of the night) is almost the same as that of total SD. The advantages of partial SD are: the patient can stand it easier, more often, and - in the company of a suited person - even at home. Finally, it is less complicate in clinical routine than selective REM-deprivation.
睡眠剥夺（SD）已被证明是一种有效的抗抑郁治疗措施（尤其是在内源性抑郁症中）。在一项新研究中，对93名抑郁症患者进行了125次睡眠剥夺检查。睡眠剥夺对内源性抑郁症的治疗益处不仅在于夜间症状缓解，还在于引发或改善睡眠剥夺后次日的典型日波动。至少需要36小时来观察这种方法的总体效果。在重度内源性抑郁症患者中，尤其是那些有典型日波动和明显躯体症状的患者，能取得最佳效果。部分睡眠剥夺（仅后半夜）的效果与完全睡眠剥夺几乎相同。部分睡眠剥夺的优点是：患者更容易耐受，可更频繁进行，并且在有合适人员陪伴的情况下甚至可以在家中进行。最后，在临床常规操作中，它比选择性快速眼动睡眠剥夺更简单。
