果蝇眼睛背腹模式的初探。
A glimpse into dorso-ventral patterning of the Drosophila eye.
机构信息
Department of Biology, University of Dayton, Dayton, Ohio 45469, USA.
出版信息
Dev Dyn. 2012 Jan;241(1):69-84. doi: 10.1002/dvdy.22764. Epub 2011 Oct 27.
Abstract
During organogenesis in all multi-cellular organisms, axial patterning is required to transform a single layer organ primordium into a three-dimensional organ. The Drosophila eye model serves as an excellent model to study axial patterning. Dorso-ventral (DV) axis determination is the first lineage restriction event during axial patterning of the Drosophila eye. The early Drosophila eye primordium has a default ventral fate, and the dorsal eye fate is established by onset of dorsal selector gene pannier (pnr) expression in a group of cells on the dorsal eye margin. The boundary between dorsal and ventral compartments called the equator is the site for Notch (N) activation, which triggers cell proliferation and differentiation. This review will focus on (1) chronology of events during DV axis determination; (2) how early division of eye into dorsal and ventral compartments contributes towards the growth and patterning of the fly retina, and (3) functions of DV patterning genes.
摘要
在所有多细胞生物的器官发生过程中，需要轴向模式化将单层器官原基转化为三维器官。果蝇眼模型是研究轴向模式化的极好模型。背腹（DV）轴确定是果蝇眼轴向模式化过程中的第一个谱系限制事件。早期的果蝇眼原基具有默认的腹侧命运，而背侧眼命运则是通过在背侧眼缘的一组细胞中起始背侧选择器基因 pannier（pnr）的表达而建立的。称为赤道的背侧和腹侧隔室之间的边界是 Notch（N）激活的部位，它触发细胞增殖和分化。这篇综述将重点介绍：（1）DV 轴确定过程中的事件时序；（2）早期将眼睛分为背侧和腹侧隔室如何有助于蝇视网膜的生长和模式化；以及（3）DV 模式化基因的功能。
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