Vitiello M V, Schwartz R S, Moe K E, Mazzoni G, Merriam G R
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Wash.
Dialogues Clin Neurosci. 2001 Sep;3(3):229-36. doi: 10.31887/DCNS.2001.3.3/mvvitiello.
Many of the body's systems that function to maintain optimal health and well-being decline with advancing age. Aerobic capacity, muscle mass, and strength all progressively decline. Significant sleep disturbances are associated with increases in morbidity and mortality. Cognition declines, impacting an older individual's ability to function independently. Interventions that could at least stabilize or possibly improve functional capacity, sleep quality, and cognitive function have the theoretical potential to prolong an older individual's ability to live independently, and interest in their possible utility is growing rapidly. One such intervention may be stimulation of the "somatotrophic" axis via growth hormone-releasing hormone (GHRH). Here we review the evidence for such somatotrophic interventions. We also report preliminary findings on the effects of chronic GHRH treatment on the somatotrophic hormones, body composition, functional status, sleep, and cognitive function of healthy older men and women from two major GHRH intervention studies, one recently completed and the other ongoing.
随着年龄的增长，身体中许多维持最佳健康和幸福状态的系统功能都会衰退。有氧能力、肌肉质量和力量都会逐渐下降。严重的睡眠障碍与发病率和死亡率的增加有关。认知能力下降，影响老年人独立生活的能力。那些至少能稳定或可能改善功能能力、睡眠质量和认知功能的干预措施，在理论上有可能延长老年人独立生活的能力，并且人们对其潜在效用的兴趣正在迅速增长。一种这样的干预措施可能是通过生长激素释放激素（GHRH）刺激“生长激素轴”。在此，我们综述了此类生长激素干预措施的证据。我们还报告了两项主要的GHRH干预研究中，慢性GHRH治疗对健康老年男性和女性的生长激素、身体成分、功能状态、睡眠和认知功能影响的初步结果，其中一项研究最近完成，另一项仍在进行中。
