Chen Chen, Wu Sanqiao, Li Xinsheng, Zhang Xiaoying, Yan Maocang
Shaanxi Key Laboratory of Resource Biology, Shaanxi University of Technology, Hanzhong 723000, China.
Sheng Wu Gong Cheng Xue Bao. 2011 Jun;27(6):846-59.
Antibacterial peptides are a family of host-defense peptides most of which are gene-encoded and produced by living organisms of all types. Antibacterial peptides are small molecular proteins with broad antimicrobial spectrum against bacteria, viruses, fungi and sometimes even as anticancer peptide. SMAP-29, a cathelicidin-like peptide derived from sheep myeloid, line alpha-helical Structure, exerts a powerful broad antimicrobial activity against different pathogens including Gram-positive and Gram-negative bacteria, fungi, viruses, parasites, spirochaetes, chlamydia and antiendotoxin activity, and particular antibacterial mechanism, rapidly to permeabilize membranes of susceptible organisms. This paper summarizes the lately research progress of SMAP-29 and Variants including the characteristics of structure, structure-activity relationships, mode of action, diverse biological functions, gene recombinant and expression. We put emphasis on the necessity of molecular design, and primary and secondary structure-based modification, to provides a strong foundation for further drug development and design of SMAP-29.
抗菌肽是一类宿主防御肽，其中大多数是基因编码的，由各种类型的生物体产生。抗菌肽是小分子蛋白质，具有广泛的抗菌谱，可对抗细菌、病毒、真菌，有时甚至作为抗癌肽。SMAP-29是一种源自绵羊骨髓的cathelicidin样肽，呈α-螺旋结构，对包括革兰氏阳性菌和革兰氏阴性菌、真菌、病毒、寄生虫、螺旋体、衣原体在内的不同病原体具有强大的广泛抗菌活性以及抗内毒素活性，其独特的抗菌机制是能迅速使易感生物体的膜通透性增加。本文综述了SMAP-29及其变体的最新研究进展，包括结构特征、构效关系、作用方式、多种生物学功能、基因重组与表达。我们强调基于分子设计以及一级和二级结构修饰的必要性，为进一步开发和设计SMAP-29药物提供坚实基础。
