无金属的 C-H 交叉偶联反应构建含氧萘基-苯联芳烃
Metal-free C-H cross-coupling toward oxygenated naphthalene-benzene linked biaryls.
机构信息
College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.
出版信息
Org Lett. 2011 Dec 2;13(23):6208-11. doi: 10.1021/ol202632h. Epub 2011 Oct 28.
PMID:22035315
Abstract
The intermolecular C-H cross-coupling between aromatic ethers has been achieved for the first time using perfluorinated hypervalent iodine(III) compounds as extreme single-electron-transfer (SET) oxidants. The demonstrations of this specific coupling could provide a direct route to valuable oxygenated mixed naphthalene-benzene biaryls 3 only, without formation of other biaryl-derived byproducts.
摘要
首次使用全氟代高价碘(III)化合物作为极端单电子转移 (SET) 氧化剂，实现了芳基醚之间的分子间 C-H 交叉偶联。这种特定偶联的证明为仅提供了一条直接途径，可获得有价值的含氧混合萘-苯联芳烃 3，而不会形成其他联芳烃衍生的副产物。
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