氟代苯酚的区域选择性氧化芳基化反应

Yu Congjun, Patureau Frederic W

Institute of Organic Chemistry, RWTH, Aachen University, Landoltweg 1, 52074, Aachen, Germany.

Angew Chem Int Ed Engl. 2019 Dec 16;58(51):18530-18534. doi: 10.1002/anie.201910352. Epub 2019 Oct 31.

A metal free and highly regioselective oxidative arylation reaction of fluorophenols is described. The relative position of the fluoride leaving group (i.e., ortho or para) controls the 1,2 or 1,4 nature of the arylated quinone product, lending versatility and generality to this oxidative, defluorinative, arylation concept.

本文描述了一种无金属且具有高度区域选择性的氟代酚氧化芳基化反应。氟离去基团的相对位置（即邻位或对位）控制着芳基化醌产物的1,2或1,4性质，赋予了这种氧化、脱氟、芳基化概念通用性和普遍性。