Ascaso Francisco J, Mateo Javier, Huerva Valentin, Cristóbal José A
Department of Ophthalmology, Lozano Blesa University Clinic Hospital, Zaragoza, Spain.
Cutan Ocul Toxicol. 2012 Jun;31(2):167-70. doi: 10.3109/15569527.2011.629325. Epub 2011 Oct 28.
Tacrolimus has been associated with several ocular adverse effects, such as optic neuropathy.
METHODOLOGY/PRINCIPAL FINDINGS: A 56-year-old woman noted sudden, severe, painless visual loss in her left eye. She had undergone liver transplantation for alcoholic related cirrhosis 6 months before. Her chronic immunosuppressive regimen consisted of prednisone and tacrolimus at dosage of 1.5 mg orally once daily. Consequently, the patient developed a left optic neuropathy.
CONCLUSION/SIGNIFICANCE: We report the first case of unilateral optic neuropathy associated with oral tacrolimus medication. Surgeons and ophthalmologists must evaluate ocular symptoms in the post-transplantation period, and suspicion should be maintained even if unilaterality or asymmetry of symptoms against a toxic etiology.
他克莫司与多种眼部不良反应有关，如视神经病变。
方法/主要发现：一名56岁女性突然出现左眼严重无痛性视力丧失。她在6个月前因酒精性肝硬化接受了肝移植。她的慢性免疫抑制方案包括泼尼松和他克莫司，剂量为每日口服1.5毫克。结果，该患者发生了左侧视神经病变。
结论/意义：我们报告了首例与口服他克莫司药物相关的单侧视神经病变病例。外科医生和眼科医生必须在移植后时期评估眼部症状，即使症状针对中毒病因存在单侧性或不对称性，也应保持怀疑。
