他克莫司视神经病变。
Tacrolimus Optic Neuropathy.
机构信息
Department of Ophthalmology (NR), Harkness Eye Institute, Columbia University, New York, New York; Deartment of Ophthalmology (KB), University of Montreal, Montreal, Quebec, Canada; Department of Ophthalmology (SL, DMC), Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; and Department of Ophthalmology (SP), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
出版信息
J Neuroophthalmol. 2018 Jun;38(2):160-166. doi: 10.1097/WNO.0000000000000635.
BACKGROUND
Tacrolimus (FK506, Prograf) is a potent immunosuppressant, which inhibits cytokine synthesis and blocks T-cell development. Optic neuropathy from tacrolimus toxicity is very uncommon but, when present, can result in severe vision loss.
METHODS
Case series and review of the literature.
RESULTS
We present 3 patients with tacrolimus optic neuropathy after bone marrow transplantation complicated by graft-vs-host disease and demonstrate the differing clinical and radiologic presentation of this presumed toxic optic neuropathy.
CONCLUSIONS
Tacrolimus optic neuropathy can manifest in a multitude of clinical presentations and can have devastating visual consequences.
背景
他克莫司（FK506，普乐可复）是一种强效免疫抑制剂，能抑制细胞因子合成并阻断 T 细胞发育。他克莫司毒性引起的视神经病变非常罕见，但一旦发生，可导致严重视力丧失。
方法
病例系列和文献复习。
结果
我们报告了 3 例骨髓移植后发生移植物抗宿主病的他克莫司视神经病变患者，并展示了这种推测性毒性视神经病变的不同临床和放射学表现。
结论
他克莫司视神经病变可表现出多种临床表现，并可导致严重的视觉后果。
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