在感染1型或2型丙肝病毒的慢性丙肝患者中，血清丙肝病毒RNA水平与胰岛素抵抗及代谢综合征无关。

Serum HCV RNA level is not associated with insulin resistance and metabolic syndrome in chronic hepatitis C patients with genotype 1 or 2 infection.

作者信息

Huang Hao-Chun, Chuang Chia-Sheng, Hsieh Yung-Yu, Chang Te-Sheng, Wei Kuo-Liang, Shen Chien-Heng, Wu Cheng-Shyong, Tung Shui-Yi

机构信息

Department of Gastroenterology, Chang Gung Memorial Hospital at Chiayi, Chang Gung University College of Medicine, Taoyuan, Taiwan.

出版信息

Chang Gung Med J. 2011 Sep-Oct;34(5):487-95.

PMID:22035893

Abstract

BACKGROUND

Previous reports have indicated that insulin resistance (IR) is associated with chronic hepatits C virus (HCV) infection. However, the correlations between IR, metabolic syndrome (MS), and serum HCV RNA levels are still controversial. The aim of this study was to determine the relationships between IR, MS, and HCV RNA in patients with chronic genotype 1 or 2 HCV infection.

METHODS

One hundred and twenty subjects with chronic genotype 1 or 2 HCV infection with complete clinical data were prospectively enrolled. Baseline and laboratory data were collected and analyzed. IR was defined as a homeostatic model assessment- IR (HOMA-IR) score > 2.5.

RESULTS

Of the 120 patients, 47 (39.2%) had a HOMA-IR > 2.5, and 42 (35%) met the criteria for MS. IR was significantly associated with a high body mass index (p < 0.0001), high waist circumference (p < 0.0001) and high triglyceride level (p = 0.025). IR was an independent predictor of MS. However, in multivariate linear regression analysis, the serum HCV RNA level was not significantly different in chronic hepatitis C patients with or without IR (p = 0.761), and with or without MS (p = 0.292).

CONCLUSIONS

IR and MS are not uncommon in patients with chronic hepatitis C. The serum HCV RNA level is not associated with the presence of IR or MS in chronic hepatitis C patients with genotype 1 or 2 infection. The impact of hepatitis C virus on IR is not dose responsive.

摘要

背景

既往报告表明胰岛素抵抗（IR）与慢性丙型肝炎病毒（HCV）感染相关。然而，IR、代谢综合征（MS）与血清HCV RNA水平之间的相关性仍存在争议。本研究旨在确定慢性1型或2型HCV感染患者中IR、MS与HCV RNA之间的关系。

方法

前瞻性纳入120例具有完整临床资料的慢性1型或2型HCV感染患者。收集并分析基线和实验室数据。IR定义为稳态模型评估-IR（HOMA-IR）评分>2.5。

结果

120例患者中，47例（39.2%）HOMA-IR>2.5，42例（35%）符合MS标准。IR与高体重指数显著相关（p<0.0001）、高腰围（p<0.0001）和高甘油三酯水平（p=0.025）。IR是MS的独立预测因素。然而，在多因素线性回归分析中，慢性丙型肝炎患者有无IR时血清HCV RNA水平无显著差异（p=0.761），有无MS时也无显著差异（p=0.292）。