Spokes R A, Ghatei M A, Bloom S R
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Life Sci. 1990;47(5):433-7. doi: 10.1016/0024-3205(90)90302-8.
Rat and porcine endothelin differ by 6 amino acids. Porcine and rat endothelin were equiactive at producing the transient fall in blood pressure in the anaesthetised rat but porcine endothelin was three times more potent at producing the subsequent sustained rise. Repeated doses of either peptide in the same rat produced a larger pressor response with each repetition, the peak response being reached more rapidly. The magnitude of the blood pressure fall did not change significantly but the first response in each rat was of longer duration than subsequent responses, especially with rat endothelin.
大鼠和猪的内皮素在6个氨基酸上存在差异。猪和大鼠的内皮素在使麻醉大鼠血压短暂下降方面具有同等活性，但猪内皮素在引起随后的持续血压升高方面的效力是大鼠内皮素的三倍。在同一只大鼠中重复给予任一肽都会使每次重复时的升压反应更大，峰值反应出现得更快。血压下降的幅度没有显著变化，但每只大鼠的首次反应持续时间比随后的反应更长，尤其是大鼠内皮素引起的反应。
