David Renaud, Piano Julie, Robert Philippe
Centre mémoire de ressources et de recherche - EA CoBTeK, CHU de Nice, université de Nice Sophia Antipolis, 06000 Nice.
Rev Prat. 2011 Sep;61(7):939-44.
Behavioural and psychological symptoms (BPSD) are now known to be frequently associated to cognitive and functional decline in Alzheimer's disease and related disorders. Recommendations for the management of BPSD have been proposed. Non-pharmacological interventions should be the first-line treatment. Anti-dementia agents (cholinesterase inhibitors, memantine) and psychotropic drugs (antipsychotics, antidepressants and anticonvulsivants) could be associated to non-pharmacological interventions only in case of limited response with non pharmacologic approaches. Low-dose antipsychotics should only be prescribed for limited periods of time, in case of psychotic and/or aggressive refractory symptoms.
现在已知行为和心理症状（BPSD）在阿尔茨海默病及相关疾病中常与认知和功能衰退相关。针对BPSD的管理已提出相关建议。非药物干预应作为一线治疗方法。仅在非药物方法疗效有限的情况下，抗痴呆药物（胆碱酯酶抑制剂、美金刚）和精神药物（抗精神病药、抗抑郁药和抗惊厥药）才可与非药物干预联合使用。低剂量抗精神病药仅应在出现精神病性和/或攻击性难治性症状时短期使用。
