Overshott Ross, Byrne Jane, Burns Alistair
University of Manchester, School of Psychiatry and Behavioural Sciences, Wythenshawe Hospital, Manchester, UK.
Expert Rev Neurother. 2004 Sep;4(5):809-21. doi: 10.1586/14737175.4.5.809.
Patients with Alzheimer's disease may suffer from noncognitive symptoms as well as cognitive symptoms, which the condition is better known for. Behavioral and psychiatric symptoms are common in patients with Alzheimer's disease and may cause great distress to them and their carers. Symptoms include agitation, aggression, wandering, shouting, depression, apathy and sleep disturbance. The safe and effective management of behavioral and psychiatric symptoms of Alzheimer's disease is one of the greatest challenges clinicians face. Traditionally, pharmacological interventions have been the mainstay of treatment but there is growing evidence for the effectiveness of a wide range of nonpharmacological measures. In this review, the evidence and appropriateness of both types of intervention for behavioral and psychiatric symptoms in Alzheimer's disease are discussed.
阿尔茨海默病患者除了会出现以该病症而闻名的认知症状外，还可能会出现非认知症状。行为和精神症状在阿尔茨海默病患者中很常见，可能会给他们及其照顾者带来极大困扰。症状包括激动、攻击行为、徘徊、喊叫、抑郁、冷漠和睡眠障碍。安全有效地管理阿尔茨海默病的行为和精神症状是临床医生面临的最大挑战之一。传统上，药物干预一直是治疗的主要手段，但越来越多的证据表明各种非药物措施也有效果。在这篇综述中，将讨论这两种干预措施对阿尔茨海默病行为和精神症状的证据及适用性。
