Obesity Research Center, The University of Tennessee, United States.
Mol Aspects Med. 2012 Feb;33(1):26-34. doi: 10.1016/j.mam.2011.10.011. Epub 2011 Oct 21.
Obesity is a major public health problem in the United States and worldwide. Further, obesity is causally linked to the pathogenesis of insulin resistance, metabolic syndrome and type-2 diabetes (T2D). A chronic low-grade inflammation occurring in adipose tissue is at least in part responsible for the obesity-induced insulin resistance. This adipose tissue inflammation is characterized by changes in immune cell populations giving rise to altered adipo/cytokine profiles, which in turn induces skeletal muscle and hepatic insulin resistance. Detailed molecular mechanisms of insulin resistance, adipose tissue inflammation and the implications of these findings on therapeutic strategies are discussed in this review.
肥胖是美国和全球的一个主要公共卫生问题。此外，肥胖与胰岛素抵抗、代谢综合征和 2 型糖尿病（T2D）的发病机制有关。脂肪组织中发生的慢性低度炎症至少部分负责肥胖引起的胰岛素抵抗。这种脂肪组织炎症的特征是免疫细胞群的变化，导致脂肪细胞/细胞因子谱的改变，进而诱导骨骼肌和肝脏胰岛素抵抗。本文综述了胰岛素抵抗、脂肪组织炎症的详细分子机制以及这些发现对治疗策略的影响。
