Department of Nuclear Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan.
Clin Imaging. 2011 Nov-Dec;35(6):437-41. doi: 10.1016/j.clinimag.2011.02.005.
The purpose of the study is to evaluate the impact of fatty liver on maximum standard uptake value (SUVmax) of liver on 2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET).
A total of 173 consecutive healthy subjects were retrospectively recruited for analysis. Subjects with acute renal disease, chronic renal disease, or malignancy were excluded. Demographic data were collected from chart records. All subjects performed whole-body FDG PET, sonography of liver, and glutamic pyruvic transaminase (GPT) level. The SUVmax of liver on FDG PET was calculated. The relationship between the severity of fatty liver and SUVmax of liver on FDG PET was analyzed.
There were significant differences in SUVmax of liver on FDG PET in four groups: no fatty liver, mild-degree, moderate-degree, and severe-degree fatty liver on sonography diagnosis (P=.041). After adjusting for possible covariates age, sex, body mass index, and GPT, there was a significantly negative correlation between the severity of fatty liver and SUVmax of liver on FDG PET (β=-.20, P<.001).
Based on the results of this study, the liver cannot be used as a comparator of extrahepatic foci of equivocal increased FDG activity in patients with fatty liver disease.
本研究旨在评估脂肪肝对氟-18-脱氧葡萄糖（FDG）正电子发射断层扫描（PET）肝脏最大标准摄取值（SUVmax）的影响。
回顾性分析了 173 例连续的健康受试者。排除了有急性或慢性肾脏疾病或恶性肿瘤的患者。从病历记录中收集了人口统计学数据。所有受试者均行全身 FDG PET、肝脏超声和谷氨酸丙酮酸转氨酶（GPT）水平检查。计算了 FDG PET 肝脏 SUVmax。分析了脂肪肝严重程度与 FDG PET 肝脏 SUVmax 的关系。
在超声诊断无脂肪肝、轻度脂肪肝、中度脂肪肝和重度脂肪肝的 4 组之间，FDG PET 肝脏 SUVmax 存在显著差异（P=.041）。在校正了可能的协变量（年龄、性别、体重指数和 GPT）后，脂肪肝严重程度与 FDG PET 肝脏 SUVmax 呈显著负相关（β=-.20，P<.001）。
基于本研究结果，在患有脂肪肝的患者中，肝脏不能作为肝脏外疑似 FDG 活性增加灶的参照。
