Department of Nuclear Medicine, Show Chwan Memorial Hospital, Changhua.
Clin Imaging. 2010 Mar-Apr;34(2):109-12. doi: 10.1016/j.clinimag.2009.05.007.
The aim of the study is to assess the relationship between serum liver enzyme level, hepatic virus infectious state, and standard uptake value of liver on 2-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET).
It is the retrospective review study from September 2005 to September 2007. A total of 354 healthy subjects referred from the Department of Community Medicine and Health Examination Center of our hospital for health screening were reviewed retrospectively and recruited for analysis. Whole-body FDG-PET, serum liver enzyme levels [aspartate aminotransferase (AST) or SGOT and alanine aminotransferase (ALT) or SGPT], and hepatic B (HBV)/hepatic C virus (HCV) infectious states by checking serum antibodies were performed in all subjects. The mean and maximal values of standard uptake values (SUV) of liver were calculated. The relationships between serum liver enzyme levels, hepatic virus infectious states, and standard uptake values of liver on FDG-PET were evaluated.
There is statistically significant positive correlation between SGOT/SGPT and SUV of liver on FDG-PET. However, there are no significant differences in the SUV of liver on FDG-PET between HBV/HCV infection and nonhepatic virus infection subjects.
High FDG uptake in the liver because of high level of SGOT/SGPT may lower the diagnostic sensitivity of hepatic malignant or infectious lesions on FDG-PET. For avoiding false-negative findings, careful evaluation of liver on FDG-PET and correlation with other clinical manifestations should be recommended in patients with high level of SGOT/SGPT. Nevertheless, neither HBV/HCV infectious states significantly influences on the SUV of liver on FDG-PET.
本研究旨在评估血清肝酶水平、肝病毒感染状态与 2-氟-2-脱氧-D-葡萄糖（FDG）正电子发射断层扫描（PET）的肝脏标准摄取值之间的关系。
这是一项回顾性研究，回顾性分析了 2005 年 9 月至 2007 年 9 月期间因健康筛查而从我院社区医学和体检中心转来的 354 名健康受试者。所有受试者均行全身 FDG-PET、血清肝酶水平[天门冬氨酸氨基转移酶（AST）或 SGOT 和丙氨酸氨基转移酶（ALT）或 SGPT]和肝 B（HBV）/肝 C 病毒（HCV）感染状态（通过检查血清抗体）。计算肝脏标准摄取值（SUV）的平均值和最大值。评估血清肝酶水平、肝病毒感染状态与 FDG-PET 肝脏 SUV 的关系。
SGOT/SGPT 与 FDG-PET 肝脏 SUV 之间存在统计学显著正相关。然而，HBV/HCV 感染和非肝病毒感染受试者之间的 FDG-PET 肝脏 SUV 无显著差异。
由于 SGOT/SGPT 水平升高，肝脏摄取大量 FDG，可能会降低 FDG-PET 对肝恶性或感染性病变的诊断敏感性。为避免假阴性结果，建议在 SGOT/SGPT 水平升高的患者中，仔细评估 FDG-PET 肝脏并与其他临床表现相关联。然而，HBV/HCV 感染状态均不显著影响 FDG-PET 肝脏 SUV。
