Department of Cardiothoracic Surgery, NYU School of Medicine, New York, New York 10016, USA.
Semin Thorac Cardiovasc Surg. 2011 Summer;23(2):137-45. doi: 10.1053/j.semtcvs.2011.07.001.
Historically, lung cancer has been viewed as a male disease, but during the past 50 years there has been a dramatic increase in the incidence of lung cancer in women. Lung cancer is currently the most common cause of cancer death in American women, accounting for more than one quarter of all cancer deaths. This has been attributed to a significant increase in tobacco consumption by women; however, approximately 1 in 5 women with lung cancer never smoked. As the incidence of lung cancer in women has increased, significant gender-based differences in epidemiology, biology, and treatment responses have become evident and warrant further investigation to advance the treatment of lung cancer in all patients.
从历史上看，肺癌一直被视为男性疾病，但在过去的 50 年中，女性肺癌的发病率急剧上升。肺癌是目前美国女性癌症死亡的最常见原因，占所有癌症死亡人数的四分之一以上。这归因于女性吸烟人数的显著增加；然而，大约每 5 名患有肺癌的女性中就有 1 名从未吸烟。随着女性肺癌发病率的增加，在流行病学、生物学和治疗反应方面出现了显著的性别差异，这需要进一步研究，以推进所有患者的肺癌治疗。
