Shaikh Z S, Krueper S, Malins T J
Department of Oral and Maxillofacial Surgery, Royal Infirmary, Princes Road, University Hospital of North Staffordshire NHS Trust, Stoke on Trent, UK.
Ann R Coll Surg Engl. 2011 Nov;93(8):569-72. doi: 10.1308/147870811X605246.
This article describes the sequence of acute clinical deterioration seen in a head and neck oncology patient who developed serotonin syndrome peri-operatively. It highlights the clinical dilemma that can be encountered when a septic picture masks the onset of serotonin syndrome and reinforces the importance of awareness of the potential interactions and side effects associated with drugs that surgeons prescribe. We discuss the pathophysiology, causal factors, clinical presentation and diagnosis of serotonin syndrome as well as highlighting some of the dilemmas that this condition presents in the surgical setting.
本文描述了一名头颈部肿瘤患者围手术期发生血清素综合征时出现的急性临床恶化过程。它强调了在脓毒症表现掩盖血清素综合征发作时可能遇到的临床困境，并强化了认识外科医生所开药物潜在相互作用和副作用的重要性。我们讨论了血清素综合征的病理生理学、病因、临床表现和诊断，同时突出了这种病症在手术环境中所呈现的一些困境。
