Chan B S, Graudins A, Whyte I M, Dawson A H, Braitberg G, Duggin G G
Department of Emergency Medicine, Prince of Wales Hospital, NSW.
Med J Aust. 1998 Nov 16;169(10):523-5. doi: 10.5694/j.1326-5377.1998.tb123399.x.
We describe six patients diagnosed with serotonin syndrome after exposure to drugs with serotonergic activity. Drug interactions occurred as a result of a combination of tricyclic antidepressants, selective serotonin reuptake inhibitors, selective noradrenaline reuptake inhibitors or monoamine oxidase inhibitors. Management included supportive care and the use of non-specific serotonin antagonists (cyproheptadine, benzodiazepines and chlorpromazine). All patients made uneventful recoveries.
我们描述了6例在接触具有血清素能活性的药物后被诊断为血清素综合征的患者。三环类抗抑郁药、选择性5-羟色胺再摄取抑制剂、选择性去甲肾上腺素再摄取抑制剂或单胺氧化酶抑制剂联合使用导致了药物相互作用。治疗措施包括支持性护理以及使用非特异性血清素拮抗剂（赛庚啶、苯二氮䓬类药物和氯丙嗪）。所有患者均顺利康复。
