PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20 Shinsuna, Tokyo 136-0075, Japan.
J Neurol Sci. 2012 Mar 15;314(1-2):111-9. doi: 10.1016/j.jns.2011.10.010. Epub 2011 Oct 30.
We performed a quantitative neuropathological examination of the hypometabolic regions on FDG PET in dementia with Lewy bodies (DLB), Alzheimer's disease (AD) and control cases. When the DLB cases were divided into two groups according to concomitant AD pathology (ADP), neuronal loss in the temporo-parietal association area was milder in the DLB groups than in the AD group, although there were no differences between the two DLB groups. Tau and Aβ immunoreactivities were observed in the AD group and the DLB group with ADP, but were rare in the DLB group without ADP. Tau and Aβ immunoreactivities as well as numbers of neurofibrillary tangles (NFTs) and neuritic plaques (NPs) were more common in the AD group than in the DLB group with ADP. There was no difference in neuronal loss in the occipital area among the three groups. α-Synuclein immunoreactivity was observed in the DLB groups but not in the AD group. There were no differences in α-synuclein immunoreactivity and number of Lewy bodies (LBs) between the two DLB groups. These findings indicate that the neuropathological bases of the hypometabolic regions in the temporo-parietal association and occipital area in DLB may be AD pathology and Lewy pathology, respectively.
我们对路易体痴呆（DLB）、阿尔茨海默病（AD）和对照组患者的 FDG PET 低代谢区域进行了定量神经病理学检查。当根据并发 AD 病理学（ADP）将 DLB 病例分为两组时，与 AD 组相比，DLB 组颞顶联合区的神经元丢失较轻，尽管两组之间没有差异。AD 组和伴有 ADP 的 DLB 组观察到 Tau 和 Aβ 免疫反应，但在不伴有 ADP 的 DLB 组中很少见。AD 组中 Tau 和 Aβ 免疫反应以及神经原纤维缠结（NFTs）和神经突斑块（NPs）的数量比伴有 ADP 的 DLB 组更为常见。三组患者的枕叶区域神经元丢失无差异。α-突触核蛋白免疫反应仅见于 DLB 组，而 AD 组未见。两组 DLB 之间的α-突触核蛋白免疫反应和路易体（LB）数量无差异。这些发现表明，DLB 患者颞顶联合区和枕叶区低代谢区域的神经病理学基础可能分别为 AD 病理学和路易体病理学。
