Sasaki Shugo, Hashimoto Koji, Nakatsuka Shin-ichi, Hasegawa Masataka, Nakano Tomoaki, Nagata Seiki, Kanakura Yuzuru, Hayashi Norio
Department of Internal Medicine, Kansai Rosai Hospital, Japan.
Intern Med. 2011;50(21):2615-20. doi: 10.2169/internalmedicine.50.4892. Epub 2011 Nov 1.
We encountered a case of plasmablastic extramedullary plasmacytoma with multiple myeloma. Histological findings revealed that the extramedullary plasmacytoma of this patient was of the plasmablastic type, which was positive for λ-stain and EBV-encoded RNA. In contrast, bone marrow aspiration demonstrated a common-type multiple myeloma, which was positive for λ-stain and negative for EBV-encoded RNA. This was a rare case of plasmablastic extramedullary plasmacytoma associated with Epstein-Barr virus arising in an immunocompetent patient with multiple myeloma.
我们遇到了一例伴有多发性骨髓瘤的浆母细胞性髓外浆细胞瘤。组织学检查结果显示，该患者的髓外浆细胞瘤为浆母细胞型，λ染色和EB病毒编码RNA呈阳性。相比之下，骨髓穿刺显示为普通型多发性骨髓瘤，λ染色呈阳性，EB病毒编码RNA呈阴性。这是一例罕见的浆母细胞性髓外浆细胞瘤，与爱泼斯坦-巴尔病毒相关，发生于一名具有免疫活性的多发性骨髓瘤患者。
