Department of Pathology, Children's Hospital of Orange County (CHOC), Orange, California, USA.
Department of Pathology and Laboratory Medicine, Kaiser Permanente Fontana Medical Center, Fontana, CA, USA.
Histol Histopathol. 2019 Jun;34(6):655-662. doi: 10.14670/HH-18-066. Epub 2018 Nov 19.
Epstein-Barr virus (EBV) expression has been reported in several hematopoietic and non-hematopoietic disorders but its expression in plasma cell neoplasms has been largely limited to immunodeficiency-related cases such as in the setting of post-organ transplantation or human immunodeficiency virus (HIV) infection. The aim of this study is to evaluate the association of EBV with plasma cell neoplasms, mainly in immunocompetent patients.
We retrospectively studied 147 cases of patients with different plasma cell neoplasms (109 plasma cell myelomas, 22 plasmacytomas, and 16 monoclonal gammopathy cases). Six patients were immunocompromised. EBV was positive in 6 cases; 3 immunocompromised (2 patients with HIV infection and 1 patient was post-renal transplant) and 3 immunocompetent patients with plasmacytoma and variable plasmablastic features.
Our data shows that EBV was negative in all plasma cell myeloma cases in immunocompetent patients and has an overall low association with the different plasma cell neoplasms in the immunocompetent setting. When expressed, it is usually associated with variable plasmablastic features.
已报道 EBV 在几种造血和非造血疾病中表达，但在浆细胞肿瘤中的表达在很大程度上仅限于与免疫缺陷相关的病例，如器官移植后或人类免疫缺陷病毒（HIV）感染。本研究旨在评估 EBV 与浆细胞肿瘤的相关性，主要针对免疫功能正常的患者。
我们回顾性研究了 147 例不同浆细胞肿瘤患者（109 例浆细胞骨髓瘤、22 例浆细胞瘤和 16 例单克隆丙种球蛋白病）。其中 6 例患者免疫功能低下。6 例 EBV 阳性；3 例免疫功能低下（2 例 HIV 感染，1 例肾移植后）和 3 例免疫功能正常的浆细胞瘤患者，伴有不同程度的浆母细胞特征。
我们的数据表明，在免疫功能正常的患者中，所有浆细胞骨髓瘤病例的 EBV 均为阴性，并且在免疫功能正常的情况下，其与不同浆细胞肿瘤的总体相关性较低。当表达时，通常与不同程度的浆母细胞特征相关。
