College of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450001, People's Republic of China.
Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jan;85(1):298-302. doi: 10.1016/j.saa.2011.10.014. Epub 2011 Oct 13.
In the present work the feasibility of β-cyclodextrin in complexation was explored, as a tool for improving the solubility and biological ability of daidzein derivatives. A series of phosphorylated daidzein derivatives featuring different chain lengths were synthesized through a modified Atherton-Todd reaction and their inclusion complexes with βCD were prepared by coprecipitation method. The inclusion complexation behavior was studied by fluorescence, UV, FT-IR, MS and (1)H NMR. The results showed that only phosphorylated daidzein derivative carrying small substituent group ((C(2)H(5)O)(2)PO) entered the cavity of βCD and formed 1:1 inclusion complex. The formation constant was 175(mol/L)(-1).
在本工作中，探索了β-环糊精作为提高大豆苷元衍生物的溶解度和生物活性的工具的配合能力。通过改良的 Atherton-Todd 反应合成了一系列具有不同链长的磷酸化大豆苷元衍生物，并通过共沉淀法制备了它们与β-CD 的包合物。通过荧光、紫外、FT-IR、MS 和（1）H NMR 研究了包合行为。结果表明，只有带有小取代基的磷酸化大豆苷元衍生物（(C(2)H(5)O)(2)PO）进入β-CD 的腔中并形成 1:1 的包合物。形成常数为 175（mol/L）（-1）。
