大豆苷元与羟丙基-β-环糊精包合物的制备
[Preparation of inclusion complex of daidzein and hydropropyl-beta-cyclodextrin].
作者信息
Ge Yue-Bin, Chen Da-Wei, Xie Li-Ping, Wang Hong-Zhong, Zheng Gui-Lan, Zhang Rong-Qing
机构信息
Center of Ocean, Department of Biology Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2006 Dec;31(24):2039-41.
OBJECTIVE
To prepare an inclusion complex of daidzein and hydropropyl-beta-cyclodextrin to enhance the solubility of daidzein.
METHOD
The inclusion complex of daidzein was prepared by the solution stirring method. The binary system of daidzein and HP-beta-CD was confirmed by differential thermal, thermogravimetry analysis, infrared spectroscopy and X-ray diffractometry.
RESULT
The drug content in the inclusion complex was 6. 76% and the solubility was 13.68 mg x mL(-1). The identification results showed that the inclusion complex was formed.
CONCLUSION
The preparation method of the inclusion complex of daidzein and hydropropyl-beta-cyclodextrin is simple and available, with a increased solubility of daidzein.
目的
制备大豆苷元与羟丙基-β-环糊精的包合物以提高大豆苷元的溶解度。
方法
采用溶液搅拌法制备大豆苷元包合物。通过差示热分析、热重分析、红外光谱和X射线衍射法对大豆苷元与羟丙基-β-环糊精的二元体系进行确证。
结果
包合物中的药物含量为6.76%，溶解度为13.68 mg·mL⁻¹。鉴定结果表明形成了包合物。
结论
大豆苷元与羟丙基-β-环糊精包合物的制备方法简便可行，大豆苷元的溶解度有所提高。
Zotero 插件