Fakoorziba M R, Eghbal F, Azizi K, Moemenbellah-Fard M D
Department of Medical Entomology, School of Health and Nutrition, Research Centre for Health Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Trop Biomed. 2011 Aug;28(2):418-24.
Linear dermatitis (or dermatitis linearis, DL) is a skin blistering inflammatory lesion caused by exposure to the pederin toxin from rove beetles. Although it is prevalent in many countries of the Middle East region, this is not a notifiable disease. In recent years, a number of clinical symptoms outbreaks of DL has been reported from a few neighboring countries of Iran, but no report of experimental treatment among small laboratory rodents is known. This is a prerequisite to ascertain the nature of the best treatment strategy in cases of infestation with these beetles, as it occurs among local settlers during hot seasons in certain parts of the southern Iranian province of Fars. Live Paederus beetles were collected, identified to species level, sexed apart and partly processed to obtain their hemolymph toxin pederin in ethanol for dermal application on guinea pigs. Two Paederus species were found. Paederus ilsae (Bernhauer) (Coleoptera: Staphylinidae) was more abundant than P. iliensis (Coiffait). Recovery from DL due to live P. ilsae beetles was quicker and less complex than that of pederin in ethanol on guinea pigs. The application of potassium permanganate with calamine to heal DL was also more effective than fluocinolone treatment. This topical corticosteroid is thus considered less able to avert the cytotoxic action of pederin on the skin of guinea pigs than the antipruritic and cleansing agents. It seems likely that fluocinolone has certain effects which delays the recovery period for the treated skin.
线状皮炎（或线状性皮炎，DL）是一种因接触隐翅虫的斑蝥素毒素而引起的皮肤水疱性炎症病变。尽管它在中东地区的许多国家都很常见，但这并非法定报告疾病。近年来，伊朗的一些邻国报告了多起DL临床症状暴发事件，但在小型实验啮齿动物中尚无实验性治疗的报告。这是确定这些甲虫侵扰病例最佳治疗策略性质的前提条件，因为在伊朗南部法尔斯省某些地区的炎热季节，当地居民中会发生这种情况。收集活的隐翅虫，鉴定到物种水平，区分性别，并部分进行处理以在乙醇中获取其血淋巴毒素斑蝥素，用于在豚鼠身上进行皮肤涂抹。发现了两种隐翅虫。伊尔萨隐翅虫（Bernhauer）（鞘翅目：隐翅虫科）比伊犁隐翅虫（Coiffait）更为常见。与用乙醇中的斑蝥素处理豚鼠相比，因活的伊尔萨隐翅虫导致的DL恢复更快且情况不那么复杂。用高锰酸钾和炉甘石治疗DL也比氟轻松治疗更有效。因此，这种局部用皮质类固醇在避免斑蝥素对豚鼠皮肤的细胞毒性作用方面，似乎不如止痒和清洁剂有效。氟轻松似乎有某些作用，会延迟治疗皮肤的恢复期。
