Kanagarajah Prashanth, Ayyathurai Rajinikanth, Saleem Umar, Manoharan Murugesan
Department of Urology, University of Miami-Miller School of Medicine, Miami, Fla., USA.
Urol Int. 2012;88(4):477-9. doi: 10.1159/000332154. Epub 2011 Oct 25.
Primary neuroendocrine carcinomas of the genitourinary tract are rare and aggressive tumors carrying a bad prognosis. With squamous cell and transitional cell carcinoma being the most commonly reported urethral malignancies, primary small cell carcinoma (SCC) of the urethra is extremely rare. To date, only 5 cases have been reported in the literature. We present the first case of primary SCC occurring in the bulbar urethra in an 89-year-old male. We discuss the clinical, histological and immunohistochemical features of SCC of the urethra. Furthermore, we summarize the available literature and discuss the possible treatment options for this rare yet aggressive neoplasm.
泌尿生殖道原发性神经内分泌癌是罕见的侵袭性肿瘤，预后不良。鳞状细胞癌和移行细胞癌是最常报道的尿道恶性肿瘤，原发性尿道小细胞癌极为罕见。迄今为止，文献中仅报道过5例。我们报告了首例发生于一名89岁男性球部尿道的原发性小细胞癌。我们讨论了尿道小细胞癌的临床、组织学和免疫组化特征。此外，我们总结了现有文献，并讨论了这种罕见但侵袭性肿瘤可能的治疗方案。
