Re Massimo, Magliulo Giuseppe, Salvolini Eleonora, Orciani Monia, Gioacchini Federico Maria, Goteri Gaia, Rubini Corrado
Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy.
Anal Quant Cytol Histol. 2010 Oct;32(5):247-53.
To examine the prognostic significance of the immunohistochemical expression of p53 and KAI-1 oncoproteins in patients with laryngeal squamous cell carcinoma.
A retrospective evaluation was developed on 82 patients with primary laryngeal squamous cell carcinoma treated by primary surgery. For the immunohistochemical evaluation, formalin-fixed and paraffin-embedded tissue blocks from resection were used. Clinicopathologic data were correlated with the staining results.
The results of the immunohistochemical examination showed a statistically significant relationship between down-regulation of KAI-1 protein expression, increase of the histologic grading, and primary tumors associated with lymph node metastases. On the other hand, no statistical correlation was evidenced between p53 up-regulation and clinicopathologic data or between the two markers.
Our results suggest that KAI-1 may become an important biomarker that could help in selection of high-risk patients with laryngeal squamous cell carcinoma who may benefit from more aggressive therapy or chemoprevention.
探讨p53和KAI-1癌蛋白免疫组化表达在喉鳞状细胞癌患者中的预后意义。
对82例接受一期手术治疗的原发性喉鳞状细胞癌患者进行回顾性评估。免疫组化评估采用切除标本经福尔马林固定、石蜡包埋的组织块。临床病理数据与染色结果相关联。
免疫组化检查结果显示，KAI-1蛋白表达下调、组织学分级增加与伴有淋巴结转移的原发性肿瘤之间存在统计学显著关系。另一方面，p53上调与临床病理数据之间或两种标志物之间均未显示出统计学相关性。
我们的结果表明，KAI-1可能成为一种重要的生物标志物，有助于筛选出可能从更积极治疗或化学预防中获益的高危喉鳞状细胞癌患者。
