[氧损伤敏感指标在早期煤工尘肺筛查中的价值]

[Value of oxygenic injury sensitive index in the screening of the early coal workers' pneumoconiosis].

作者信息

Fan Hongmin, Yuan Juxiang, Qin Tianbang, Qiu Hongyan, Wang Zhuo, Ren Jingxue

机构信息

Department of Preventive Medicine, School of Public Health, Heibei United University, Tangshan 063000, China.

出版信息

Wei Sheng Yan Jiu. 2011 Sep;40(5):579-82.

PMID:22043706

Abstract

OBJECTIVE

To study the significance of oxidative injury in the screening of coal workers' pneumoconiosis (CWP).

METHODS

With the method of nitrate reductase, TBA, et al, the content of NO, MDA and other indexes of peroxidation in plasma lipid were detected in 112 patients suffering from coal workers' pneumoconiosis and 114 healthy coal workers as controls.

RESULTS

There were statistical significant between two groups (P < 0.05) with the content or density of MDA, CuZn-SOD, GSH-Px, T-AOC, UA, NO and iNOS except CP. As screening index of pneumoconiosis, there were statistical significant in area under the curve (AUC) of MDA, T-AOC, NO and iNOS between the two groups by ROC. As screening index of pneumoconiosis, MDA, T-AOC, NO and iNOS can be selected as early screening index. Especially, T-AOC was the best index of four indexes (sensitivity is 70.5%, specificity is 68.1%).

CONCLUSION

Joint screening of MDA, T-AOC and iNOS is better than single index or series of T-AOC and MDA to the screening of CWP.

摘要

目的

探讨氧化损伤在煤工尘肺（CWP）筛查中的意义。

方法

采用硝酸还原酶法、TBA法等，检测112例煤工尘肺患者及114例健康煤工作为对照的血浆脂质中NO、MDA等过氧化指标的含量。

结果

两组间MDA、CuZn-SOD、GSH-Px、T-AOC、UA、NO和iNOS的含量或密度差异有统计学意义（P<0.05），除CP外。作为尘肺筛查指标，两组间MDA、T-AOC、NO和iNOS的ROC曲线下面积（AUC）差异有统计学意义。作为尘肺筛查指标，MDA、T-AOC、NO和iNOS可作为早期筛查指标。尤其是，T-AOC是四个指标中最佳指标（敏感性为70.5%，特异性为68.1%）。