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与含石棉干墙配件产品接触相关的潜在健康危害:科学评估现状。

Potential health hazards associated with exposures to asbestos-containing drywall accessory products: A state-of-the-science assessment.

机构信息

ChemRisk LLC, Chicago, IL, USA.

出版信息

Crit Rev Toxicol. 2012 Jan;42(1):1-27. doi: 10.3109/10408444.2011.613067. Epub 2011 Nov 1.

Abstract

Until the late 1970s, chrysotile asbestos was an ingredient in most industrial and consumer drywall accessory products manufactured in the US. In 1977, the Consumer Product Safety Commission (CPSC) issued a ban of consumer patching compounds containing "respirable, free-form asbestos" based on their prediction of exceptionally high rates of asbestos-related diseases among individuals using patching compounds for as little as a few days. Although hundreds of thousands of workers and homeowners handling these products may have experienced exposure to asbestos prior to the ban, there has been no systematic effort to summarize and interpret the information relevant to the potential health effects of such exposures. In this analysis, we provide a comprehensive review and analysis of the scientific studies assessing fiber type and dimension, toxicological and epidemiological endpoints, and airborne fiber concentrations associated with joint compound use. We conclude that: 1) asbestos in drywall accessory products was primarily short fiber (< 5 µm) chrysotile, 2) asbestos in inhaled joint compound particulate is probably not biopersistent in the lung, 3) estimated cumulative chrysotile exposures experienced by workers and homeowners are below levels known to be associated with respiratory disease, and 4) mortality studies of drywall installers have not demonstrated a significantly increased incidence of death attributable to any asbestos-related disease. Consequently, contrary to the predictions of the CPSC, the current weight of evidence does not indicate any clear health risks associated with the use of asbestos-containing drywall accessory products. We also describe information gaps and suggest possible areas of future research.

摘要

直到 20 世纪 70 年代末,温石棉仍是美国制造的大多数工业和消费用干墙配件产品的成分。1977 年,美国消费品安全委员会(CPSC)发布了一项禁令,禁止含有“可吸入、自由形态石棉”的消费修补化合物,理由是他们预测,使用这些修补化合物的人,即使只使用了几天,也会患上极高比例的与石棉有关的疾病。尽管在禁令之前,成千上万处理这些产品的工人和房主可能已经接触到了石棉,但并没有系统地努力总结和解释与这些接触相关的潜在健康影响的信息。在这项分析中,我们对评估纤维类型和尺寸、毒理学和流行病学终点以及与使用补缝剂相关的空气中纤维浓度的科学研究进行了全面回顾和分析。我们的结论是:1)干墙配件产品中的石棉主要是短纤维(<5µm)温石棉;2)吸入的补缝剂颗粒中的石棉在肺部可能不是生物持久性的;3)工人和房主估计累积暴露于温石棉的水平低于已知与呼吸道疾病相关的水平;4)干墙安装工的死亡率研究并未表明与任何与石棉有关的疾病相关的死亡发生率显著增加。因此,与 CPSC 的预测相反,目前的证据并没有表明使用含石棉的干墙配件产品与任何明确的健康风险有关。我们还描述了信息空白,并提出了未来可能的研究领域。

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