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更新评估与含石棉干墙附属产品暴露相关的潜在健康危害。

An updated evaluation of potential health hazards associated with exposures to asbestos-containing drywall accessory products.

机构信息

Cardno ChemRisk, Arlington, VA, USA.

Cardno ChemRisk, San Francisco, CA, USA.

出版信息

Crit Rev Toxicol. 2019 May;49(5):430-444. doi: 10.1080/10408444.2019.1639612. Epub 2019 Aug 5.

Abstract

Following a previously published (2012) evaluation of the potential health hazards related to the use of asbestos-containing drywall accessory products, additional information regarding asbestos exposures during the use of accessory products, as well as studies of chrysotile asbestos risk as a function of exposure, have been published in the peer-reviewed literature. The purpose of this analysis is to update the original evaluation with this new information. It was previously estimated that a professional drywaller performing joint compound-associated tasks could have a lifetime cumulative chrysotile exposure of 12-26 f/cc-year. Using conservative assumptions regarding airborne asbestos levels during different drywalling tasks, task duration, and job tenure, we found that a range of 4.3-36.3 f/cc-year is a plausible estimate of a career drywaller's cumulative asbestos exposure from historical joint compound use. The estimated range for bystander exposures would be below (sometimes significantly below) this range depending on the frequency and duration of work near drywallers. Further, the estimated drywaller and bystander total fiber exposures were well below a recently published "no-observed adverse effect level, best estimate" for predominately chrysotile exposures of 89-168 f/cc-year for lung cancer and 208-415 f/cc-year for mesothelioma. We also determined that, even if the chrysotile or possibly talc ingredients in the drywall products had contained asbestiform tremolite, the cumulative tremolite exposures would have been well below a recently published tremolite no-effect level of 0.5-2.6 f/cc-year. Based on our calculations, typical drywall work using asbestos-containing drywall accessory products is not expected to increase the risk of asbestos-related lung cancer or mesothelioma. These conclusions are consistent with the lack of epidemiological evidence that drywall work resulted in an increased incidence of asbestos-related disease in the drywall trades.

摘要

继先前发表的(2012 年)有关使用含石棉干墙配件产品相关健康危害的评估后,更多关于在使用配件产品期间石棉暴露的信息,以及将温石棉石棉风险作为暴露函数的研究,已在同行评议文献中发表。本分析的目的是用这些新信息更新原始评估。此前估计,从事腻子粉相关任务的专业干墙工可能会有 12-26 纤维/立方厘米年的终生累计温石棉暴露量。使用不同干墙任务期间、任务持续时间和工作年限期间空气中石棉水平的保守假设,我们发现,职业干墙工从历史上使用腻子粉获得的累积石棉暴露量的范围为 4.3-36.3 纤维/立方厘米年是一个合理的估计。根据靠近干墙工工作的频率和持续时间,旁观者的暴露量估计范围将低于(有时大大低于)此范围。此外,估计的干墙工和旁观者总纤维暴露量远低于最近发表的“无观察到不良效应水平,最佳估计”,即主要为温石棉暴露量为 89-168 纤维/立方厘米年的肺癌和 208-415 纤维/立方厘米年的间皮瘤。我们还确定,即使干墙产品中的温石棉或可能的滑石成分含有纤维状透闪石,累积的透闪石暴露量也将远低于最近发表的透闪石无效应水平 0.5-2.6 纤维/立方厘米年。根据我们的计算,使用含石棉干墙配件产品的典型干墙工作预计不会增加与石棉相关的肺癌或间皮瘤的风险。这些结论与没有流行病学证据表明干墙工作导致干墙行业与石棉相关的疾病发病率增加是一致的。

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