IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy Institute of Psychiatry, Catholic University, Rome, Italy.
Addict Biol. 2013 Jul;18(4):749-51. doi: 10.1111/j.1369-1600.2011.00411.x. Epub 2011 Nov 1.
Although the pathophysiology of gambling is unknown, an involvement of midbrain dopaminergic pathway has been hypothesized. In this study, the association between brain-derived neurotrophic factor (BDNF) and pathological gambling was investigated. We measured BDNF serum levels in (1) video players (n=10); (2) card players (n=9); (3) mixed players (n=21; both video and card players) and (4) age-matched controls (n=18). Mixed players had increased BDNF serum levels as compared to controls and higher South Oaks Gambling Screen score as compared to card or video players. Thus, the data demonstrate that patients affected by severe pathological gambling show enhanced BDNF serum levels.
虽然赌博的病理生理学尚不清楚，但已经假设中脑多巴胺能通路的参与。在这项研究中，研究了脑源性神经营养因子（BDNF）与病理性赌博之间的关系。我们测量了（1）视频玩家（n=10）；（2）纸牌玩家（n=9）；（3）混合玩家（n=21；视频和纸牌玩家）和（4）年龄匹配的对照组（n=18）的血清 BDNF 水平。与对照组相比，混合玩家的血清 BDNF 水平升高，与纸牌或视频玩家相比，他们的 South Oaks Gambling Screen 评分更高。因此，这些数据表明，患有严重病理性赌博的患者显示出增强的 BDNF 血清水平。
