双相情感障碍患者在抑郁发作和躁狂发作期间血清脑源性神经营养因子水平降低。
Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes.
作者信息
Cunha Angelo B M, Frey Benicio N, Andreazza Ana C, Goi Júlia D, Rosa Adriane R, Gonçalves Carlos A, Santin Aida, Kapczinski Flavio
机构信息
Department of Neuropsychiatry, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Faixa de Camobi Km 9, 97105 900 Santa Maria, RS, Brazil.
出版信息
Neurosci Lett. 2006 May 8;398(3):215-9. doi: 10.1016/j.neulet.2005.12.085. Epub 2006 Feb 9.
Genetic and pharmacological studies have suggested that brain-derived neurotrophic factor (BDNF) may be associated with the pathophysiology of bipolar disorder (BD). The present study investigated serum BDNF levels in manic, depressed, euthymic BD patients and in matched healthy controls, using an enzyme-linked immunosorbent assay (sandwich-ELISA). Serum BDNF levels were decreased in manic (p=0.019) and depressed (p=0.027) BD patients, as compared with euthymic patients and controls. Serum BDNF levels were negatively correlated with the severity of manic (r=-0.37, p=0.005) and depressive (r=-0.30, p=0.033) symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD.
遗传学和药理学研究表明，脑源性神经营养因子（BDNF）可能与双相情感障碍（BD）的病理生理学有关。本研究采用酶联免疫吸附测定法（夹心酶联免疫吸附测定法），对躁狂、抑郁、心境正常的双相情感障碍患者以及匹配的健康对照者的血清BDNF水平进行了调查。与心境正常的患者和对照者相比，躁狂（p=0.019）和抑郁（p=0.027）的双相情感障碍患者血清BDNF水平降低。血清BDNF水平与躁狂（r=-0.37，p=0.005）和抑郁（r=-0.30，p=0.033）症状的严重程度呈负相关。这些发现进一步支持了BDNF信号系统可能在双相情感障碍的病理生理学中起作用这一假说。
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