Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Cell Commun Signal. 2011 Nov 1;9(1):29. doi: 10.1186/1478-811X-9-29.
Helicobacter pylori colonizes the human gastric epithelium and induces chronic gastritis, which can lead to gastric cancer. Through cell-cell contacts the gastric epithelium forms a barrier to protect underlying tissue from pathogenic bacteria; however, H. pylori have evolved numerous strategies to perturb the integrity of the gastric barrier. In this review, we summarize recent research into the mechanisms through which H. pylori disrupts intercellular junctions and disrupts the gastric epithelial barrier.
幽门螺杆菌定植于人类胃上皮细胞并引发慢性炎症，进而导致胃癌。通过细胞-细胞接触，胃上皮形成屏障以保护下层组织免受病原菌的侵害；然而，幽门螺杆菌已经进化出许多策略来破坏胃屏障的完整性。在这篇综述中，我们总结了最近关于幽门螺杆菌破坏细胞间连接和破坏胃上皮屏障的机制的研究。
