Han C M
Dept. of Burns & Plastic Surgery, Second Affiliated Hospital of Zhejiang Medical University.
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1990 Jun;6(2):83-6, 155.
The trace elements and the effect of zinc sulphate on wound healing of 46 severely burned patients in recent 2 years were studied. By double blind method 22 patients accepted capsular ZnSO4 (660 mg) per day as treated group and 24 patients medical starch as control. ZnSO4 and placebo were taken from 3rd or 5th day post burn until healing. Serum and 24h urine Zn and Cu were measured on days 3, 5, 9, 13 post burn and later weekly until healing. The changes of Zn and Cu in serum and urine in all patients were similar to the results reported by others. But the serum Zn on day 9 and urine Zn on days 5, 9, 13 post burn in treated group were significantly higher than that in control group. The basic wound healing time was same in both groups, but the patients in treated group whose coefficient UBS* (Unit of Burned Surface) was more than 180 were cured 8 days earlier than the patients of same severity in control group. At the healing the serum Zn in treated group was significantly higher than that in normal control group, while the serum Zn in control group was as same as in normal control group. The rising to normal of value of Zn/Cu in treated group was significantly earlier than that in control group. But the linear regression equations of serum Zn and Cu, urine Zn and Cu in both groups have no significant difference in the whole course of disease. No side effects of ZnSO4 have been found during the course.(ABSTRACT TRUNCATED AT 250 WORDS)
研究了近2年46例重度烧伤患者的微量元素及硫酸锌对伤口愈合的影响。采用双盲法，22例患者每天接受胶囊硫酸锌（660毫克）作为治疗组，24例患者接受医用淀粉作为对照组。硫酸锌和安慰剂从烧伤后第3天或第5天开始服用，直至伤口愈合。在烧伤后第3、5、9、13天及之后每周测量血清和24小时尿锌和铜，直至伤口愈合。所有患者血清和尿液中锌和铜的变化与其他人报道的结果相似。但治疗组烧伤后第9天的血清锌及第5、9、13天的尿锌显著高于对照组。两组基本伤口愈合时间相同，但治疗组中烧伤面积系数UBS*（烧伤面积单位）大于180的患者比对照组中相同严重程度的患者提前8天治愈。愈合时，治疗组的血清锌显著高于正常对照组，而对照组的血清锌与正常对照组相同。治疗组锌/铜比值恢复正常的时间显著早于对照组。但两组血清锌和铜、尿锌和铜的线性回归方程在疾病全过程中无显著差异。在治疗过程中未发现硫酸锌的副作用。（摘要截短至250字）
