Khorasani G, Hosseinimehr S J, Kaghazi Z
Department of Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Singapore Med J. 2008 Aug;49(8):627-30.
Burn injury is a medical problem as well as a social burden on the national health services in developing countries. Trace elements have important roles in wound healing and act as antioxidants. In this study, zinc (Zn) and copper (Cu) levels in plasma of burned patients and their relationship with the burn surface area and time-related pattern are determined in the admitted patients after burn injury.
37 patients were divided into two groups: Group 1 consisted of 16 patients with burn injuries less than 20 percent of the total burn surface area, and Group 2 consisted of 21 patients with burn injuries between 20 and 40 percent of the total burn surface area. The control group consisted of 20 subjects. The Zn and Cu levels were determined one, three, seven and 14 days after the occurrence of burn injury. These trace elements were determined using atomic absorption spectrophotometer.
These trace elements in plasma significantly decreased on all days after admission and the levels were lower than those of the control group. There was no significant relationship between Groups 1 and 2 in Cu and Zn concentrations on different days. We did not find any difference between burn surface area and Zn and Cu concentrations in these groups.
Based on the critical role of plasma's Zn and Cu rate in wound healing and their relationship in decreasing the burn injury, it is important that patients having burn types II and III take Zn and Cu supplements continuously as micronutrients after burn injury.
烧伤是一个医学问题，也是发展中国家国家卫生服务的社会负担。微量元素在伤口愈合中起重要作用，并作为抗氧化剂。在本研究中，测定了烧伤患者血浆中的锌（Zn）和铜（Cu）水平及其与烧伤表面积和时间相关模式的关系，这些患者均为烧伤后入院者。
37例患者分为两组：第1组由16例烧伤面积小于总体表面积20%的患者组成，第2组由21例烧伤面积在总体表面积20%至40%之间的患者组成。对照组由20名受试者组成。在烧伤发生后的第1、3、7和14天测定Zn和Cu水平。使用原子吸收分光光度计测定这些微量元素。
入院后所有天数血浆中的这些微量元素均显著降低，且水平低于对照组。在不同天数，第1组和第2组的Cu和Zn浓度之间没有显著关系。我们在这些组中未发现烧伤表面积与Zn和Cu浓度之间存在任何差异。
鉴于血浆中Zn和Cu比率在伤口愈合中的关键作用及其在减轻烧伤损伤方面的关系，II度和III度烧伤患者在烧伤后持续补充Zn和Cu作为微量营养素非常重要。
