Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA.
J Clin Invest. 2011 Nov;121(11):4210-21. doi: 10.1172/JCI45161. Epub 2011 Nov 1.
Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease. Better understanding of the cellular pathophysiological processes underlying kidney injury and repair will hopefully result in the design of more targeted therapies to prevent the injury, hasten repair, and minimize chronic progressive kidney disease.
缺血性肾损伤常发生在多器官衰竭和脓毒症的背景下。在这里，我们回顾了这一动态过程的主要组成部分，包括血流动力学改变、炎症、内皮和上皮细胞损伤，以及随后的修复，修复可以是适应性的，恢复上皮完整性，也可以是失调性的，导致慢性肾脏病。更好地了解肾脏损伤和修复的细胞病理生理过程，有望设计出更有针对性的治疗方法来预防损伤、加速修复，并最大限度地减少慢性进行性肾脏病。
