肾脏纤维化中的上皮-间充质转化（EMT）：事实还是幻想？
Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
机构信息
Department of Anatomy and Developmental Biology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
出版信息
J Clin Invest. 2011 Feb;121(2):468-74. doi: 10.1172/jci44595.
Abstract
Epithelial-mesenchymal transition (EMT) has become widely accepted as a mechanism by which injured renal tubular cells transform into mesenchymal cells that contribute to the development of fibrosis in chronic renal failure. However, an increasing number of studies raise doubts about the existence of this process in vivo. Herein, we review and summarize both sides of this debate, but it is our view that unequivocal evidence supporting EMT as an in vivo process in kidney fibrosis is lacking.
摘要
上皮-间充质转化（EMT）已被广泛接受为一种机制，即受伤的肾小管细胞转化为间充质细胞，有助于慢性肾衰竭中纤维化的发展。然而，越来越多的研究对这一过程在体内的存在提出了质疑。在此，我们对这一争论的双方进行了回顾和总结，但我们认为，支持 EMT 作为肾脏纤维化体内过程的明确证据是缺乏的。
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