Decker R S, Donta S T, Larsen W J, Murray S A
J Supramol Struct. 1978;9(4):497-507. doi: 10.1002/jss.400090405.
Initial studies of adrenocorticotropin-sensitivity (ACTH-sensitive) and ACTH-insensitive Y-1 adrenal cortical tumor cell lines suggest a relationship between responsiveness to ACTH and the presence of gap junctions. An ACTH-sensitive clone of Y-1 cells possesses gap junctions and these junctions appear to enlarge with ACTH treatment. GAP junctions have not been observed, however, in an ACTH-insensitive clone of Y-1 tumor cells even when stimulated to produce cyclic adenosine monophosphate and steroids with cholera toxin.
对促肾上腺皮质激素敏感性（ACTH敏感）和ACTH不敏感的Y-1肾上腺皮质肿瘤细胞系的初步研究表明，对ACTH的反应性与间隙连接的存在之间存在关联。Y-1细胞的一个ACTH敏感克隆具有间隙连接，并且这些连接在ACTH处理后似乎会增大。然而，在Y-1肿瘤细胞的ACTH不敏感克隆中未观察到间隙连接，即使在用霍乱毒素刺激其产生环磷酸腺苷和类固醇时也是如此。
