Ficarra G, Gaglioti D, Riccardi R, Di Pietro M, Nardi P
Istituto di Odontostomatologia, Università degli Studi di Firenze.
Minerva Stomatol. 1990 Jun;39(6):453-9.
Oral hairy leukoplakia is a new clinicopathological entity. Little is known about its etiology, pathogenesis and natural history. It is considered a specific marker of HIV infection, although it has been also reported in HIV-negative patients. The etiology appears related to Epstein-Barr virus. Hairy leukoplakia has a characteristic clinical and histopathological aspect, but it is not specific. Because hairy leukoplakia may be easily confused with other lesions of the tongue, the dentist should be very careful in making the final diagnosis. Hairy leukoplakia is usually asymptomatic and treatment is not necessary. In cases of extensive lesions or psychological intolerance of the patient, useful drugs are acyclovir and vitamin A derivatives.
口腔毛状白斑是一种新的临床病理实体。对其病因、发病机制和自然史了解甚少。它被认为是HIV感染的一种特异性标志物，尽管在HIV阴性患者中也有报道。病因似乎与爱泼斯坦-巴尔病毒有关。毛状白斑有特征性的临床和组织病理学表现，但并不具有特异性。由于毛状白斑可能很容易与舌部的其他病变相混淆，牙医在做出最终诊断时应非常谨慎。毛状白斑通常无症状，无需治疗。对于病变广泛或患者心理上难以耐受的情况，有用的药物是阿昔洛韦和维生素A衍生物。
