Department of Pathology and Laboratory Medicine, University of Louisville Hospital, KY 40202, USA.
Ann Diagn Pathol. 2013 Feb;17(1):127-30. doi: 10.1016/j.anndiagpath.2011.06.004. Epub 2011 Nov 1.
Metastasis to breast from extramammary tissue is rare, and endometrial cancer has rarely been reported to metastasize to the breast. An extensive search in the medical literature reveals only 2 cases. They can be easily mistaken for primary breast carcinoma both clinically and radiologically, even with known history of endometrial carcinoma. This report presents a case of a 64-year-old woman who had endometrial carcinoma treated with total hysterectomy and adjuvant radiation and chemotherapy. Three years after the diagnosis, she had evidence of a solitary breast metastasis. To our knowledge, this is the third described case of endometrial cancer metastatic to the breast and the first in which the endometrial carcinoma demonstrates significant clear cell changes. This report is a reminder that although rare, endometrial carcinoma has the potential to metastasize to breast and illustrates how metastatic lesions in the breast can masquerade clinically as a primary carcinoma. Furthermore, essential guidelines necessary to distinguish primary from metastatic lesions in the breast are presented.
来自乳腺外组织的转移至乳腺的情况较为罕见，而子宫内膜癌转移至乳腺的情况则更为罕见。在医学文献中进行广泛检索仅发现 2 例。即使已知有子宫内膜癌病史，它们在临床和影像学上也可能很容易被误诊为原发性乳腺癌。本报告介绍了一例 64 岁女性的病例，该患者患有子宫内膜癌，接受了全子宫切除术和辅助放疗及化疗。在诊断后 3 年，她出现了孤立性乳腺转移的证据。据我们所知，这是第三例描述的子宫内膜癌转移至乳腺的病例，也是首例显示明显透明细胞改变的病例。本报告提醒人们，尽管罕见，但子宫内膜癌有转移至乳腺的潜力，并说明了乳腺中的转移病灶如何在临床上伪装为原发性癌。此外，还提出了在乳腺中区分原发性和转移性病变所需的基本指导原则。
