Department of Electronic Engineering, City University of Hong Kong, Kowloon.
Phys Biol. 2011 Dec;8(6):066004. doi: 10.1088/1478-3975/8/6/066004. Epub 2011 Nov 2.
Nucleosomes, which contain DNA and proteins, are the basic unit of eukaryotic chromatins. Polymers such as DNA and proteins are dynamic, and their conformational changes can lead to functional changes. Periodic dinucleotide patterns exist in nucleosomal DNA chains and play an important role in the nucleosome structure. In this paper, we use normal mode analysis to detect significant structural deformations of nucleosomal DNA and investigate the relationship between periodic dinucleotides and DNA motions. We have found that periodic dinucleotides are usually located at the peaks or valleys of DNA and protein motions, revealing that they dominate the nucleosome dynamics. Also, a specific dinucleotide pattern CA/TG appears most frequently.
核小体，包含 DNA 和蛋白质，是真核染色质的基本单位。DNA 和蛋白质等聚合物是动态的，它们的构象变化会导致功能变化。核小体 DNA 链中存在周期性二核苷酸模式，在核小体结构中起着重要作用。在本文中，我们使用正常模式分析来检测核小体 DNA 的显著结构变形，并研究周期性二核苷酸与 DNA 运动之间的关系。我们发现周期性二核苷酸通常位于 DNA 和蛋白质运动的峰或谷处，这表明它们主导着核小体的动力学。此外，特定的二核苷酸模式 CA/TG 出现的频率最高。
