Department of Molecular and Cellular Biology, Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
EMBO J. 2011 Nov 2;30(21):4340-1. doi: 10.1038/emboj.2011.373.
EMBO J 30 21, 4414–4422 (2011); published online September 30 2011 Micro RNAs (miRNAs) are 21–23 nucleotide long RNAs that associate with the Argonaute family of proteins and direct interactions of these and RNA-induced silencing complex (RISC) components to the 3′-UTRs of mRNAs that harbour partially complementary sequences. The paradigm for miRNA function has been that they inhibit gene expression by translational inhibition and subsequent mRNA degradation. However, a series of recent studies have revealed that subsets of miRNAs are also localized in the nucleus, suggesting that they perform different functions in this cellular compartment. In this issue of , Hansen et al (2011) describe that nuclear localized miRNAs target non-coding RNAs (ncRNAs) revealing an intriguing and novel mechanism for gene regulation.
EMBO J 30 21, 4414–4422 (2011); published online September 30 2011 微 RNA（miRNA）是 21-23 个核苷酸长的 RNA，与 Argonaute 家族蛋白结合，并指导这些蛋白和 RNA 诱导沉默复合物（RISC）组分与 3'UTR 上含有部分互补序列的 mRNAs 结合。miRNA 功能的范例是通过翻译抑制和随后的 mRNA 降解来抑制基因表达。然而，一系列最近的研究表明，一部分 miRNA 也定位于细胞核内，这表明它们在这个细胞区室中具有不同的功能。在本期的 中，Hansen 等人（2011 年）描述了定位于细胞核内的 miRNA 靶向非编码 RNA（ncRNA），揭示了一种有趣的新的基因调控机制。
