Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province, Department of Physiology, Shanxi Medical University, Taiyuan 030001, China.
Int J Mol Sci. 2023 Feb 20;24(4):4233. doi: 10.3390/ijms24044233.
Non-coding RNAs have been excavated as important cardiac function modulators and linked to heart diseases. Significant advances have been obtained in illuminating the effects of microRNAs and long non-coding RNAs. Nevertheless, the characteristics of circular RNAs are rarely mined. Circular RNAs (circRNAs) are widely believed to participate in cardiac pathologic processes, especially in myocardial infarction. In this review, we round up the biogenesis of circRNAs, briefly describe their biological functions, and summarize the latest literature on multifarious circRNAs related to new therapies and biomarkers for myocardial infarction.
非编码 RNA 已被挖掘为重要的心脏功能调节剂，并与心脏疾病相关。在阐明 microRNAs 和长非编码 RNA 的作用方面已经取得了重大进展。然而，环状 RNA 的特征很少被挖掘。环状 RNA（circRNAs）被广泛认为参与心脏病理过程，特别是心肌梗死。在这篇综述中，我们总结了 circRNAs 的生物发生，简要描述了它们的生物学功能，并总结了关于与心肌梗死的新疗法和生物标志物相关的多种 circRNAs 的最新文献。
