通过 N-轴向手性 Pd 配合物催化的不对称烯丙基化反应，实现了 Morita-Baylis-Hillman 加合物的高效动力学拆分。
A highly efficient kinetic resolution of Morita-Baylis-Hillman adducts achieved by N-Ar axially chiral Pd-complexes catalyzed asymmetric allylation.
机构信息
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 MeiLong Road, Shanghai 200237, PR China.
出版信息
Chem Commun (Camb). 2011 Dec 28;47(48):12813-5. doi: 10.1039/c1cc15543a. Epub 2011 Nov 3.
PMID:22048620
Abstract
Palladium complexes with an axially chiral N-Ar framework have been developed. These complexes showed high stereoselectivities in asymmetric allylic arylation to achieve the kinetic resolution of Morita-Baylis-Hillman adducts, affording up to 99% ee of (E)-allylation products and 92% ee of recovered Morita-Baylis-Hillman adducts.
摘要
已开发出具有轴向手性 N-Ar 骨架的钯配合物。这些配合物在不对称烯丙基芳基化反应中表现出高立体选择性，实现了 Morita-Baylis-Hillman 加合物的动力学拆分，得到高达 99%ee 的（E）-烯丙基化产物和 92%ee 的回收 Morita-Baylis-Hillman 加合物。
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