Department of Psychology, University of Auckland, New Zealand; Department of Molecular Medicine, Faculty of Medicine and Health Science, University of Auckland, Private Bag 92019, Auckland, New Zealand.
J Health Psychol. 2000 Jan;5(1):99-108. doi: 10.1177/135910530000500102.
Advances in DNA technology have facilitated presymptomatic testing for an inherited predisposition to a number of autosomal dominant cancer syndromes. While testing is generally undertaken with informed consent and within a counselling protocol, there is still much to be learned about the psychological impact of DNA testing in a predictive setting. In this study, patients' experiences were recorded using in-depth interview techniques following earlier testing for hereditary non-polyposis colorectal cancer which was coordinated through an hereditary cancer registry. Thematic analysis of the transcripts revealed consistent issues pertaining to identity as well as emotional responses to previous preventative strategies and ongoing cancer screening options.
DNA 技术的进步促进了对许多常染色体显性遗传癌综合征的遗传易感性的症状前检测。虽然检测通常是在知情同意和咨询协议的框架内进行的,但在预测性环境下,关于 DNA 检测的心理影响还有很多需要学习。在这项研究中,使用深入访谈技术记录了患者的经历,这些患者在遗传性非息肉病性结直肠癌(由遗传性癌症登记处协调)的早期检测后接受了测试。对转录本的主题分析揭示了与身份相关的一致问题,以及对先前预防策略和持续的癌症筛查选择的情绪反应。